Involvement of Macrophage Migration Inhibitory Factor (MIF) in Experimental Uric Acid Nephropathy
نویسندگان
چکیده
منابع مشابه
Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathy.
BACKGROUND Deposition of uric acid in the kidney can lead to progressive tubulointerstitial injury with granuloma formation. We hypothesized that uric acid crystal deposition may induce granuloma formation by stimulating local expression of macrophage migration inhibitory factor (MIF), which is a known mediator of delayed type hypersensitivity (DTH). MATERIALS AND METHODS A model of acute uri...
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متن کاملCurrent developments of macrophage migration inhibitory factor (MIF) inhibitors.
The cytokine macrophage migration inhibitory factor (MIF) is regarded as a major regulator of inflammation and a key mediator that counter-regulates the inhibitory effects of glucocorticoids within the immune system. Therefore, MIF is a therapeutic target for the treatment of inflammatory and autoimmune diseases. In addition, MIF was found to be implicated in cancer pathogenesis. Current therap...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2000
ISSN: 1076-1551,1528-3658
DOI: 10.1007/bf03401822